Constanza Manuel of Villena (ca. 1316 – 27 January 1349), was a Castilian noblewoman who by her two marriages was Queen consort of Castile and León and Infanta of Portugal. Early years and first marriage: Queen of Castile [ edit ]
Constanza Manuel - Wikipedia
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Constanza Manuel of Villena (ca. 1316 – 27 January 1349), was a Castilian noblewoman who by her two marriages was Queen consort of Castile and León and Infanta of Portugal. Early years and first marriage: Queen of Castile [ edit ]
Constanza Manuel was born in 1316 as the daughter of Juan Manuel, Prince of Villena and Duke of Peñafiel and Constance of Aragon, a daughter of James II of Aragon. Still only a child she married Alfonso XI of Castile on 28 November 1325. She was Queen for just two short years. Alfonso dissolved the marriage and quickly remarried [read more]
Manuel, Constanza. ?, c. 1313 – Santarem (Portugal), 13.XI.1345. Noble, esposa del infante Pedro de Portugal y madre del rey portugués Fernando I. Fruto de la unión entre don Juan Manuel, nieto de Fernando III de Castilla, y Constanza, hija de Jaime II de Aragón y nieta del rey de Nápoles, unía en sus venas la sangre real con la de uno ...
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Significado: Fiel, constante. De origen latino.
Manuel Antonio Noriega Moreno ( / mɑːnˈwɛl nɔːriˈeɪɡə / i, mahn-WEL nor-ee-AY-gə; Spanish pronunciation: [maˈnwel noˈɾjeɣa]; February 11, 1934 – May 29, 2017) [a] was a Panamanian dictator, politician and military officer who was the de facto ruler of Panama from 1983 to 1989.
Purpose The incidence of breast cancer in young women (BCYW) has increased in recent decades. Malignant disease in this subset is characterized by its aggressiveness and poor prognosis. Ovarian function suppression (OFS) in these patients improves survival especially in hormone receptor-positive (HR +) cases. The Regan Composite Risk (RCR) is a prognostic tool to identify high-risk HR + BC ...
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Constanza Manuel of Villena, was a Castilian noblewoman who by her two marriages was Queen consort of Castile and León and Infanta of Portug... Wikipedia
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