Paxlovid rebound is a term used to describe when a person experiences worsening of COVID symptoms after initially getting better after taking Paxlovid. But COVID rebound isn’t a side effect of Paxlovid. It can happen to people taking any COVID treatment, as well as to people who received no treatment at all.
There have been reports of a “rebound” of COVID-19 symptoms in some people within 2 to 8 days after completing the five-day course of Paxlovid; in those cases, some have tested positive again but have no symptoms; others have a recurrence of symptoms.
When Paxlovid is stopped, the virus starts replicating again. It’s possible that Paxlovid may need to be given for a longer period of time – maybe seven or 10 days instead of five days. Those ...
A June preprint study shows 3.53% of people may experience a rebound within 7 days of taking Paxlovid, but the rate of symptomatic rebound is only 2.31%. After 30 days, the chance of a COVID rebound after Paxlovid increases slightly to 5.4%. Some researchers suspect more people may be rebounding after Paxlovid than we think.
Nirmatrelvir/ritonavir, sold under the brand name Paxlovid, is a co-packaged medication used as a treatment for COVID‑19. It contains the antiviral medications nirmatrelvir and ritonavir and was developed by Pfizer.
A study that reveals how the virus mutates to escape Paxlovid could now help chemists design better drugs that are more difficult for SARS-CoV-2 to sidestep. The study, led by researchers at Columbia University and several universities in China, was published Sept. 11 in Nature.
Escape mutations in SARS-CoV-2 In the study, Iketani and colleagues looked at how mutations allow the virus to evade nirmatrelvir. Images of the drug when bound to its viral target, Mpro, revealed...
Rebound is not limited to people who have taken Paxlovid; symptoms can flare up again after resolving even among people who do not take the medication. Paxlovid is one of the most effective treatments available for people with mild-to-moderate COVID, lowering the risk of hospitalization or death significantly.
- What is the Paxlovid rebound?YouTube
- Paxlovid Rebound: What Is Happening?YouTube
- How Long Does Paxlovid COVID Rebound Last? What Experts Say on Puzzling Cases | NBC New YorkYouTube
- What is COVID Rebound After Paxlovid? A Doctor ExplainsYouTube