If you experience Paxlovid rebound, it’s important to isolate yourself to avoid getting others sick. Stay home for at least 5 days. After that, continue to wear a mask around others for another 5 days. Your first day of Paxlovid rebound symptoms would be considered “Day 0.”.
For more information about viral rebound and the recurrence of COVID-19 symptoms, refer to the NIH COVID-19 Treatment Guidelines: Ritonavir-Boosted Nirmatrelvir (Paxlovid). Paxlovid Fact Sheet for Healthcare Providers FAQs on the Emergency Use Authorization for Paxlovid for Treatment of COVID-19 Paxlovid Eligibility Checklist
'Viral rebound' after completing Paxlovid treatment Paxlovid, an oral antiviral Covid-19 treatment, was first authorized for emergency use by FDA in December. According to clinical trial data, the drug was able to reduce the risk of hospitalization or death by almost 90% in unvaccinated patients at high risk of severe Covid-19 outcomes, leading ...
The treatment consists of two drugs — nirmatrelvir and ritonavir — which work together to suppress SARS-CoV-2 by blocking an enzyme that allows the virus to replicate in the body. It is easier to take at home compared to drugs like Remdesivir, which require intravenous injection.
Paxlovid treatment helps prevent hospitalization and death due to COVID-19. COVID-19 rebound has been reported to occur between 2 and 8 days after initial recovery and is characterized by a recurrence of COVID-19 symptoms or a new positive viral test after having tested negative.
If your COVID-19 symptoms return after you finish Paxlovid, you should isolate yourself again for at least five days. After five days, if you have gone a full day without any signs of a fever, you can leave isolation. However, you should still wear a mask for 10 days after your symptoms started again.
Cases of Covid-19 rebound following treatment with the antiviral medication Paxlovid – where infections rev back up again after people complete their five-day course of the medication –...
It’s also unclear how often rebound occurs after treatment for COVID-19. Some research suggests it happens in about 3 to 5 percent of people who take Paxlovid or molnupiravir, another oral antiviral treatment for COVID. The good news: When rebound does happen, it tends to be “very mild,” Lawrence says.
The treatment consists of three different drugs, and if the patient doesn’t get a high enough dose of nirmatrelvir—the part of Paxlovid that targets COVID-19 enzymes—pockets of SARS-CoV-2 may survive. Those remaining traces may cause viral levels to climb back up days after treatment stops.
There is currently no evidence that a second round of Paxlovid treatment is needed after the initial 5-day treatment if COVID-19 rebound occurs. Case reports suggest that people who develop COVID rebound after completing 5 days of Paxlovid treatment usually have no symptoms or mild illness.